We previously showed that TBK1 is a gene that causes glaucoma by altering autophagy. Autophagy is a process by which cells engulf and digest cell components. Cells may use autophagy as a source of energy in times of nutritional deprivation. We have shown that TBK1 gene defects (duplications and triplications) cause excess autophagy, which can damage vital cell components and lead to cell death and ultimately to glaucoma. This new publication outlines standards for the research community to follow when studying autophagy. Read the guidelines here.
Mon, 01/25/2016 - 11:00
Fri, 01/15/2016 - 10:15
As part of the NEIGHBORHOOD consortium of glaucoma genetics labs in the US, we co-authored a Nature Genetics report that identified three new risk factors for glaucoma: TXNRD2, ATXN2, and FOXC1. The discovery of more risk factors is a significant step forward in the science and care of glaucoma. Read more about it here.
Mon, 12/14/2015 - 19:15
Lab contributes to an article reviewing discussions focusing on the exfoliation glaucoma at the Glaucoma Foundation’s Glaucoma Think Tank in New York.” Read more about this article here.