DEDICATED TO DISCOVERING THE CAUSES AND THE CURES FOR GLAUCOMA

LAB NEWS

MYOC Glaucoma
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Dr. Fingert is named a Gold Fellow of the Association for Research in Vision and Ophthalmology

The title of ARVO Fellow is an honor established to recognize current ARVO members for their individual accomplishments, leadership and contributions to the Association.

 

Read more about the FARVO awards here.

OUR MAJOR PROJECTS

John Fingert Glaucoma Genetics Lab Cell Culture
TBK1 GENE
AND NORMAL TENSION GLAUCOMA

We discovered that TBK1 gene duplications or triplications are one of the most common known causes of normal tension glaucoma. We continue to study how mutations in TBK1 cause glaucoma using human donor eyes, stem cell biology, and transgenic animals. Read more about this research here.

John Fingert Glaucoma Genetics Lab PCR

OUR PUBLICATIONS

Click here to see all of our publications on PUBMED

Select publications described below:

Familial Glaucoma—A Pedigree Revisited With Genetic Testing After 70 Years
JAMA Ophthalmology, 2022, in press

In this manuscript, we report detection of a MYOC mutation in a juvenile glaucoma pedigree first described by Dr. Frey and Dr. Posner in 1952. Read more about this manuscript here.

OUR MAJOR DISCOVERIES

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• Discovery of the first glaucoma gene (MYOC)
• Discovery of a low pressure glaucoma gene (TBK1)
• Engineering transgenic mice that develop low pressure glaucoma due to TBK1 gene mutation
• Creating induced pluripotent stem cells (iPSCs) with TBK1 mutations
• First genetic studies of Ocular Hypertension Treatment Study (OHTS)​

• First Exome study of Pigmentary Glaucoma