MYOCILIN GLAUCOMA PUBLICATIONS

The articles we have published on myocilin glaucoma are listed below in chronological order.

Click on the Title to access the manuscript on PUBMED

1

Identification of a gene that causes primary open angle glaucoma.

Stone EM, Fingert JH, Alward WL, Nguyen TD, Polansky JR, Sunden SL, Nishimura D, Clark AF, Nystuen A, Nichols BE, Mackey DA, Ritch R, Kalenak JW, Craven ER, Sheffield VC.

Science. 1997 Jan 31;275(5300):668-70. PMID: 9005853

2

Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A).

Alward WL, Fingert JH, Coote MA, Johnson AT, Lerner SF, Junqua D, Durcan FJ, McCartney PJ, Mackey DA, Sheffield VC, Stone EM.

N Engl J Med. 1998 Apr 9;338(15):1022-7. PMID: 9535666 

3

Characterization and comparison of the human and mouse GLC1A glaucoma genes.

Fingert JH, Ying L, Swiderski RE, Nystuen AM, Arbour NC, Alward WL, Sheffield VC, Stone EM.

Genome Res. 1998 Apr;8(4):377-84. PMID: 9548973

4

A novel Asp380Ala mutation in the GLC1A/myocilin gene in a family with juvenile onset primary open angle glaucoma.

Kennan AM, Mansergh FC, Fingert JH, Clark T, Ayuso C, Kenna PF, Humphries P, Farrar GJ.

J Med Genet. 1998 Nov;35(11):957-60. PMID: 9832047 

5

Analysis of myocilin mutations in 1703 glaucoma patients from five different populations.

Fingert JH, Héon E, Liebmann JM, Yamamoto T, Craig JE, Rait J, Kawase K, Hoh ST, Buys YM, Dickinson J, Hockey RR, Williams-Lyn D, Trope G, Kitazawa Y, Ritch R, Mackey DA, Alward WL, Sheffield VC, Stone EM.

Hum Mol Genet. 1999 May;8(5):899-905. PMID: 10196380

6

Normal range of hearing associated with myocilin Thr377Met.

Simm RM, Fingert JH, Craig JE, McNaught AI, Mackey DA.

Ophthalmic Genet. 1999 Sep;20(3):205-7. PMID: 10610189 

7

The genetic aspects of adult-onset glaucoma: a perspective from the Greater Toronto area.

Williams-Lyn D, Flanagan J, Buys Y, Trope GE, Fingert J, Stone EM, Héon E.

Can J Ophthalmol. 2000 Feb;35(1):12-7. PMID: 10711378

8

Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization.

Swiderski RE, Ross JL, Fingert JH, Clark AF, Alward WL, Stone EM, Sheffield VC.

Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3420-8.PMID: 11006234

9

Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension.

Fingert JH, Clark AF, Craig JE, Alward WL, Snibson GR, McLaughlin M, Tuttle L, Mackey DA, Sheffield VC, Stone EM.

Invest Ophthalmol Vis Sci. 2001 Jan;42(1):145-52.PMID: 11133859

10

Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor.

Jacobson N, Andrews M, Shepard AR, Nishimura D, Searby C, Fingert JH, Hageman G, Mullins R, Davidson BL, Kwon YH, Alward WL, Stone EM, Clark AF, Sheffield VC.

Hum Mol Genet. 2001 Jan 15;10(2):117-25. PMID: 11152659

11

Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head.

Clark AF, Kawase K, English-Wright S, Lane D, Steely HT, Yamamoto T, Kitazawa Y, Kwon YH, Fingert JH, Swiderski RE, Mullins RF, Hageman GS, Alward WL, Sheffield VC, Stone EM.

FASEB J. 2001 May;15(7):1251-3. PMID: 11344104 

12

Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues.

Clark AF, Steely HT, Dickerson JE Jr, English-Wright S, Stropki K, McCartney MD, Jacobson N, Shepard AR, Clark JI, Matsushima H, Peskind ER, Leverenz JB, Wilkinson CW, Swiderski RE, Fingert JH, Sheffield VC, Stone EM.

Invest Ophthalmol Vis Sci. 2001 Jul;42(8):1769-80.PMID: 11431441

13

Evidence for genetic heterogeneity within eight glaucoma families, with the GLC1A Gln368STOP mutation being an important phenotypic modifier.

Craig JE, Baird PN, Healey DL, McNaught AI, McCartney PJ, Rait JL, Dickinson JL, Roe L, Fingert JH, Stone EM, Mackey DA.

Ophthalmology. 2001 Sep;108(9):1607-20. PMID: 11535458

14

Delayed secondary glucocorticoid responsiveness of MYOC in human trabecular meshwork cells.

Shepard AR, Jacobson N, Fingert JH, Stone EM, Sheffield VC, Clark AF.

Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3173-81.PMID: 11726619

15

Variations in the myocilin gene in patients with open-angle glaucoma.

Alward WL, Kwon YH, Khanna CL, Johnson AT, Hayreh SS, Zimmerman MB, Narkiewicz J, Andorf JL, Moore PA, Fingert JH, Sheffield VC, Stone EM.

Arch Ophthalmol. 2002 Sep;120(9):1189-97. PMID: 12215093

16

Myocilin glaucoma.

Fingert JH, Stone EM, Sheffield VC, Alward WL.

Surv Ophthalmol. 2002 Nov-Dec;47(6):547-61. PMID: 12504739 

17

Glaucoma phenotype in pedigrees with the myocilin Thr377Met mutation.

Mackey DA, Healey DL, Fingert JH, Coote MA, Wong TL, Wilkinson CH, McCartney PJ, Rait JL, de Graaf AP, Stone EM, Craig JE.

Arch Ophthalmol. 2003 Aug;121(8):1172-80. PMID: 12912696

18

The optic nerve head in myocilin glaucoma.

Hewitt AW, Bennett SL, Fingert JH, Cooper RL, Stone EM, Craig JE, Mackey DA.

Invest Ophthalmol Vis Sci. 2007 Jan;48(1):238-43. PMID: 17197538

19

Myocilin Gly252Arg mutation and glaucoma of intermediate severity in Caucasian individuals.

Hewitt AW, Bennett SL, Richards JE, Dimasi DP, Booth AP, Inglehearn C, Anwar R, Yamamoto T, Fingert JH, Héon E, Craig JE, Mackey DA.

Arch Ophthalmol. 2007 Jan;125(1):98-104. PMID: 17210859

20

Primary open-angle glaucoma.

Kwon YH, Fingert JH, Kuehn MH, Alward WL.

N Engl J Med. 2009 Mar 12;360(11):1113-24. PMID: 19279343 

21

Primary open-angle glaucoma genes.

Fingert JH.

Eye. 2011 May;25(5):587-95. PMID: 21562585 

22

Clinical and genetic characterization of a large primary open angle glaucoma pedigree.

Kader MA, Namburi P, Ramugade S, Ramakrishnan R, Krishnadas SR, Roos BR, Periasamy S, Robin AL, Fingert JH.

Ophthalmic Genet. 2017 May-Jun;38(3):222-225. PMID: 27355837 

23

CRISPR-Cas9-based treatment of myocilin-associated glaucoma.

Jain A, Zode G, Kasetti RB, Ran FA, Yan W, Sharma TP, Bugge K, Searby CC, Fingert JH, Zhang F, Clark AF, Sheffield VC.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11199-11204. PMID: 28973933 

24

Penetrance of Myocilin Mutations-Who Gets Glaucoma?

Fingert JH.

JAMA Ophthalmol. 2019 Jan 1;137(1):35-37. PMID: 30267050 

25

Myocilin Mutations in Patients With Normal-Tension Glaucoma.

Alward WLM, van der Heide C, Khanna CL, Roos BR, Sivaprasad S, Kam J, Ritch R, Lotery A, Igo RP Jr, Cooke Bailey JN, Stone EM, Scheetz TE, Kwon YH, Pasquale LR, Wiggs JL, Fingert JH; NEIGHBORHOOD Consortium.

JAMA Ophthalmol. 2019 May 1;137(5):559-563. PMID: 30816940 

26

Histochemical Analysis of Glaucoma Caused by a Myocilin Mutation in a Human Donor Eye.

van der Heide CJ, Alward WLM, Flamme-Wiese M, Riker M, Syed NA, Anderson MG, Carter K, Kuehn MH, Stone EM, Mullins RF, Fingert JH.

Ophthalmol Glaucoma. 2018 Sep-Oct;1(2):132-138. PMID: 30906929 

27

Mendelian genes in primary open angle glaucoma.

Sears NC, Boese EA, Miller MA, Fingert JH.

Exp Eye Res. 2019 Sep;186:107702. PMID: 31238079 

28

Gonioscopy-Assisted Transluminal Trabeculotomy for Myocilin Juvenile Glaucoma.

Boese EA, Alward WLM, Fingert JH.

Ophthalmol Glaucoma. 2021 Jul 14:S2589-4196(21)00171-X. PMID: 34273563